Objective To investigate whether quantitative electroencephalography (QEEG) could be used to monitor atropine intoxication in treating organic phosphate poisoning.
Methods Ninety Sprague-Dawley rats were randomly divided into 9 groups:blank group (n=10),parathion group (n=10),exposure groups (n=70).The exposure groups were peritoneal injected parathion (5 mg/kg) and atropine (10,20,50,100,200,500 and 750 mg/kg respectively),the blank and the patathion group were injected with corn oil (5 mg/kg) and parathion (5 mg/kg) respectively.The QEEG were detected at 0,5,10,20,30,60 and 120 min after injection,and electrocardiogram and ethologic parameters were observed simultaneously.
Results The δ amplitude increased accordingly with the atropine dosage increase.The amplitudes of δ spectrum were 7.52& #177;0.33,7.14& #177;0.37,7.38& #177;1.36,7.80& #177;0.68,16.26& #177;1.77,29.24& #177;2.74,31.41& #177;2.94 and 36.17& #177;2.37 at the parathion and parathion combined with gradient dosage atropine groups (10,20,50,100,200,500,750mg/kg) respectively.The atropine dosages correlated with δ spectrum amplitude of the QEEG (r=0.946,P=0.000).The scores of epilepsy increased dependently with the atropine dosage raising when using the Racine' epilepsy evaluating system.
Conclusion The amplitude of δ spectrum could reflect fluctuation of atropine dosages sensitively,the epilepsy grading could be used to evaluate rat's ethology in atropine intoxication.
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