CYP1A1*2C Gene Polymorphisms in Miao, Buyi Populations of Chinese Guizhou Province

ZHENG Bo; HUANG Hai-yan; ZHANG Bing; WANG Xiao-mei; LIU Jian-jun

ZHENG Bo , HUANG Hai-yan , ZHANG Bing , WANG Xiao-mei , LIU Jian-jun . CYP1A1*2C Gene Polymorphisms in Miao, Buyi Populations of Chinese Guizhou Province[J]. Journal of Environmental and Occupational Medicine, 2010, 27(9): 560-562.

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CYP1A1^*2C Gene Polymorphisms in Miao, Buyi Populations of Chinese Guizhou Province

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Abstract

Objective To investigate the gene polymorphisms of CYP1A1^*2C in Chinese Miao, Buyi nationalities.

Methods Taqman-MGB probe was used in real-time RealTime-PCR to test the polymorphisms of CYP1A1^*2C in Chinese Miao(125), Buyi(122)people, and the significant difference between Miao and Buyi was checked by χ² test.

Results The distribution of wild homozygote(genetic type AA), mutant heterozygote(genetic type AG), mutant homozygote(genetic type GG)of CYP1A1^*2C in Chinese Miao, Buyi populations were 65.6%, 28.0%, 6.4% and 68.9%, 25.4%, 5.7%, respectively. The distribution of A and G allele frequency of CYP1A1^*2C in Miao, Buyi populations were 79.6%, 20.4% and 81.6%, 18.4%, respectively.

Conclusion The distribution of genetic frequency and allele gene frequency of CYP1A1^*2CC are without statistically significance in difference between Miao, Buyi nationalities in Guizhou Province China.

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CYP1A1^*2C Gene Polymorphisms in Miao, Buyi Populations of Chinese Guizhou Province