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SUN He-tao , JI Hai-xu , ZHOU Yuan-zhong , FAN Qi-yuan . Effects of Soy Isoflavone on Gene Expression of P450scc, MIS and ERβ in Male Offspring Rats[J]. Journal of Environmental and Occupational Medicine, 2011, 28(1): 32-34.
Citation: SUN He-tao , JI Hai-xu , ZHOU Yuan-zhong , FAN Qi-yuan . Effects of Soy Isoflavone on Gene Expression of P450scc, MIS and ERβ in Male Offspring Rats[J]. Journal of Environmental and Occupational Medicine, 2011, 28(1): 32-34.
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Effects of Soy Isoflavone on Gene Expression of P450scc, MIS and ERβ in Male Offspring Rats

    Abstract
  • Objective To explore the effects of soy isoflavone(SIF)on offspring male rats reproductive system after pregnancy exposure.

    Methods 40 pregnant rats were divided into five groups randomly. Soy isoflavone was delivered to the pregnant rats by gavage (peanut oil worked as solution, was delivered to control group)during the period of E13~E19, with the doses of 0 (control group), 25, 50, 150, 450 mg/kg. On postnatal day 18, F1 male rats were sacrificed, testicular tissues were obtained, the expression of P450scc, MIS, ERβ mRNA in testis were measured by real-time PCR.

    Results Compared with the control group, the expressions of ERβ (P < 0.01)and P450scc (P > 0.05)were deceased by exposed to different doses of SIF, but MIS expression increased (150, 450 mg/kg SIF, P < 0.01).

    Conclusion SIF could alter reproductive-related gene expressions in the offspring male rat testes, which could lead to certain adverse effects.

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